We are interested in understanding the molecular control underlying the development of connections between the retina and the visual processing areas of the brain such as the optic tectum. We are interested in the role of microtubule- and actin-based intracellular transport in this process, focusing also on their relevance to neurodegenerative pathologies in humans. In addition, we are looking at the role of a novel family of secreted proteins called meteorin and meteorin-like that may contribute to the development of axons crossing the midline of the nervous systems (commissural axons). Finally, we have identified a novel population of commissural neurons in the zebrafish visual system and we are dissecting their role in shaping the binocular properties in our favorite animal model.

Research Aeras

• Axonal transport, neuronal development and neurodegeneration.
• Meteorin and Meteorin-like protein receptor(s) and their functions in neuronal development.
• Binocular properties of tectal neurons and the role of intertectal connectivity in this neural circuit activity during prey capture.