The human brain contains billions of neurons connected by an even greater number of synapses, forming the intricate networks that drive perception and behavior. In our lab, we study how these networks process sensory information and adapt to changing contexts.

From the drifting attention of a daydreamer to the sharp focus of a climber mid-move, perception depends on brain states that constantly shift. This flexibility is a hallmark of healthy cortical function — and its loss contributes to disorders such as schizophrenia and depression.

Using a multidisciplinary approach that combines electrophysiology, two-photon imaging, optogenetics, and computational modeling, we explore how neurons and circuits in the visual and somatosensory cortices transform sensory input. Our ultimate goal is to reveal how these mechanisms are altered in disease and to identify new targets for therapeutic intervention.

Main techniques

Electrophysiology (in vivo and in vitro), two-photon calcium imaging (in vivo and in vitro), optogenetics, computational modeling, immunohistochemistry, and high-resolution imaging.

Address :
Hôpital Pitié-Salpêtrière 47 bd de l’Hôpital 75013 Paris

Team leader :
REBOLA Nelson
Name of co-team leader :

Administrative Contact Name :


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Key words : #Perception sensorielle# traitement sensoriel# réseaux neuronaux# transmission synaptique# dynamique in vivo# circuits neuronaux# neurones inhibiteurs# récepteurs NMDA. #sensory perception# sensory processing# neuronal networks# synaptic transmission# in vivo dynamics# neural circuits# inhibitory neurons# NMDA receptors.