The team aims to elucidate the role of innate and adaptive immune cells in myelin destruction and repair in multiple sclerosis, target innate immunity as therapeutic mediators in inherited white matter disorders (i.e., leukodystrophies), and decipher the code that control macrophage activation states (inflammatory vs regenerative).​

Main techniques

Human immune cells isolation and characterization, FAC analysis and sorting, Chimeric human/mouse models of de-re-myelination, immunostainings, electron microscopy, single nuclei rnaseq, multi omic analysis, spatial transcriptomic, multimodal brain imaging.

Address :
Hôpital Pitié-Salpêtrière 47 bd de l’Hôpital 75013 Paris

Team leader :
MOCHEL Fanny
Name of co-team leader :
Violetta Zojovic
Administrative Contact Name :


Website : Cliquez ici
Key words : #Immunité# Métabolisme# Neurodégénérescence# Myéline# Sclérose en plaques# Leukodystrophies #Immunité# Metabolism# Neurodegeneration# Myelin# Multiple sclerosis# Leukodystrophies