Neuronal circuit organization Emergent brain dynamics and behavior

Neuronal circuit modulation by neuromodulators & bodily signals

Sleep and memory consolidation Mathematical and computational analysis of neuronal activity

Main techniques

Large-scale in vivo electrophysiology (Neuropixels, silicon probes) in awake, behaving mice Fiber photometry for real-time neuromodulator dynamics

Optical imaging: miniature microscopes (miniscopes), two-photon imaging

Optogenetics & chemogenetics to manipulate identified circuits Transgenic mouse lines and viral vectors for targeting and circuit identification In vivo genome editing (CRISPR/Cas) to modify gene expression with cell-type and circuit specificity Quantitative signal analysis: oscillations, synchrony, population coding, dimensionality reduction

Mathematical modeling: network models, dynamical systems, reservoir computing

Statistical machine learning for decoding neuronal activity and state classification

Cross-modal data integration: linking electrophysiology, imaging, and neuromodulator measurements

Address :
Hôpital Pitié-Salpêtrière 47 bd de l’Hôpital 75013 Paris

Team leader :
KARALIS Nikolas
Name of co-team leader :

Administrative Contact Name :


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Key words : Circuits neuronaux#Dynamiques cérébrales et oscillations#Neuromodulateurs#Respiration#Électrophysiologie in vivo#Photométrie par fibre optique#Optogénétique#Traitement du signal#Analyse statistique des données#Neurosciences computationnelles Neuronal circuits#Brain dynamics and oscillations#Neuromodulators#Breathing#in vivo electrophysiology#Fiber#photometry#Optogenetics#Signal processing#Statistical data analysis#Computational neuroscience