Neurodegenerative diseases, Amyotrophic Lateral Sclerosis (ALS), motor neurons, neuroinflammation, microglia, macrophages, iPS cells, genetics

• mechanisms of motor neuron degeneration in Amyotrophic Lateral Sclerosis (ALS)

• genetic causes of ALS

• neuro-immune interactions (motor neurons – microglia/macrophages)

• modelling ALS using iPSC-derived cells and neuro-organoids

• study of ALS heterogeneity

• study of risk factors (genetics and aging)

• Anatomopathological studies

Main techniques used :

Transgenic mouse models; cell culture models : primary mouse or human cell cultures, cultures derived from iPSC; neuro-organoid models; transcriptomics; genetics

Address :
Hôpital Pitié-Salpêtrière 47 bd de l’Hôpital 75013 Paris

Team leader :
BOILLEE Severine
Name of co-team leader :

Administrative Contact Name :


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Key words : #Neurodégénérescence#motoneurone#Sclérose Latérale Amyotrophique (SLA)/ maladie de Charcot# neuroinflammation# neuroimmunologie# microglie/macrophage# iPSC#neuro-organoïdes# génétique #Neurodegeneration# motor neuron# Amyotrophic Lateral Sclerosis (ALS)#neuroinflammation# neuroimmunology# microglia/ macrophage# iPSC# neuro-organoids# genetics