Neurodegenerative diseases, Amyotrophic Lateral Sclerosis (ALS), motor neurons, neuroinflammation, microglia, macrophages, iPS cells, genetics

The team’s goal is to identify pathways as therapeutic targets for slowing disease progression through 2 approaches:

To understand how mutations in known or identifiable genes cause motoneuron death and microglial dysfunction.

Discovering new therapeutic targets related to the immune system and the periphery (rather than the central nervous system (easier to access than the brain) by modulating the response of peripheral macrophages to spinal cord motoneuron degeneration.

Main techniques used :

Address :
Hôpital Pitié-Salpêtrière 47 bd de l’Hôpital 75013 Paris

Team leader :
BOILLEE Severine
Name of co-team leader :

Administrative Contact Name :


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Key words : Sclérose Latérale Amyotrophique (SLA), motoneurones, neuroinflammation, cellules iPS, génétique Amyotrophic Lateral Sclerosis (ALS), motor neurons, neuroinflammation, iPS cells, genetics